Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

Nienke Vrisekoop; Judith N Mandl; Ronald N Germain

doi:10.1186/jbiol198

Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

J Biol. 2009;8(10):91. doi: 10.1186/jbiol198.

Authors

Nienke Vrisekoop^#¹, Judith N Mandl^#¹, Ronald N Germain¹

Affiliation

¹ Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr MSC-1892, Bethesda, MD, USA.

^# Contributed equally.

Abstract

Detailed analysis of T cell dynamics in humans is challenging and mouse models can be important tools for characterizing T cell dynamic processes. In a paper just published in Journal of Biology, Marques et al. suggest that a mouse model with its activated CD4(+) T cells are deleted has relevance for HIV infection.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / virology
CD8-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / virology
Disease Models, Animal
HIV / pathogenicity*
HIV Infections / immunology*
HIV Infections / virology
Lymphocyte Activation
Mice
Mice, Transgenic

Grants and funding

Intramural NIH HHS/United States