Hepatitis C treatment concomitant to chemotherapy as "salvage" therapy in children with hematologic malignancies

Pediatr Infect Dis J. 2010 Mar;29(3):277-80. doi: 10.1097/INF.0b013e3181c2115a.

Abstract

In patients with malignancies, chronic hepatitis C reactivation or severe flare is uncommon and antiviral treatment is deferred mainly due to underlying bone marrow and immune suppression. We report the use of antiviral treatment concomitantly to chemotherapy in 3 children with hematologic malignancies, chronic hepatitis C, and significant liver dysfunction.

Publication types

  • Case Reports

MeSH terms

  • Alanine Transaminase / blood
  • Antineoplastic Agents / therapeutic use*
  • Antiviral Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Hematologic Neoplasms / complications*
  • Hematologic Neoplasms / drug therapy*
  • Hepatitis C, Chronic / drug therapy*
  • Humans
  • Liver / pathology
  • Liver Function Tests
  • Male
  • Salvage Therapy / methods*
  • Treatment Outcome
  • Viral Load

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Alanine Transaminase