A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+)

Ying Zhou; Ha Na Kim; Juyoung Yoon

doi:10.1016/j.bmcl.2009.11.028

A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+)

Bioorg Med Chem Lett. 2010 Jan 1;20(1):125-8. doi: 10.1016/j.bmcl.2009.11.028. Epub 2009 Nov 13.

Authors

Ying Zhou¹, Ha Na Kim, Juyoung Yoon

Affiliation

¹ Department of Chemistry and Nano Science Ewha Womans University, Seoul 120-750, Republic of Korea.

PMID: 19945868
DOI: 10.1016/j.bmcl.2009.11.028

Abstract

A simple and effective fluorescent sensor based on hydrazone-pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn(2+), and application of this probe to detect the intrinsic Zn(2+) ions present in pancreatic beta-cells was successfully demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Diagnostic Imaging
Fluorescent Dyes / chemistry*
Humans
Hydrazones / chemical synthesis
Hydrazones / chemistry*
Hydrazones / pharmacology
Insulin-Secreting Cells / metabolism
Perylene / analogs & derivatives*
Perylene / chemical synthesis
Perylene / chemistry
Perylene / pharmacology
Pyrenes / chemical synthesis
Pyrenes / chemistry*
Pyrenes / pharmacology
Spectrometry, Fluorescence
Zinc / chemistry*

Substances

Fluorescent Dyes
Hydrazones
Pyrenes
Perylene
Zinc