Tetranortriterpenoids from Chisocheton paniculatus

J Nat Prod. 2009 Nov;72(11):2014-8. doi: 10.1021/np900485t.

Abstract

Seven new tetranortriterpenoids (1-7), named chisonimbolinins A-G, were isolated from twigs of Chisocheton paniculatus. Their structures were elucidated on the basis of extensive spectroscopic analyses, and the structure of 1 was confirmed by a single-crystal X-ray diffraction study. Cytotoxic activity of compounds 1-7 was evaluated using HeLa and SMMC-7721 tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • HeLa Cells
  • Humans
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Limonins / pharmacology
  • Meliaceae / chemistry*
  • Molecular Conformation
  • Molecular Structure

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Limonins