Abstract
The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers' outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC(50) in a cell-based HIV-infection model but also a high general cytotoxicity.
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemical synthesis
-
Anti-HIV Agents / chemistry*
-
Anti-HIV Agents / pharmacology*
-
Cell Line
-
Cell Survival
-
Dendrimers / chemical synthesis
-
Dendrimers / chemistry
-
Dendrimers / pharmacology
-
Galactosylceramides / chemical synthesis
-
Galactosylceramides / chemistry*
-
Galactosylceramides / pharmacology*
-
HIV Infections / drug therapy*
-
HIV-1 / drug effects*
-
Humans
-
Microbial Sensitivity Tests
-
Organophosphonates / chemical synthesis
-
Organophosphonates / chemistry
-
Organophosphonates / pharmacology
Substances
-
Anti-HIV Agents
-
Dendrimers
-
Galactosylceramides
-
Organophosphonates