The purpose of the present article was to report a case of central giant cell granuloma (CGCG) associated with intralesional corticosteroid injections. Although benign, the CGCG may be locally aggressive, causing extensive bone destruction, tooth displacement, and root resorption. The common therapy is surgery, which may result in important facial deformity and loss of teeth or dental germs. In this article, an 8-year-old girl who presented with maxillary CGCG was treated with a solution of equal parts of triamcinolone actinide (10 mg/ml) and 0.5% bupivacaine injected into the lesion for a period of 11 weeks. The osseous neoformation was gradual. After 6-years follow-up, clinical and radiographic success of treatment were observed. Based on our results and the literature available, the administration of intralesional corticosteroid injections is an alternative in CGCG treatment, especially in children.