Background: Psoriatic arthritis often affects patients with psoriasis.
Objective: To examine the effect of adalimumab on psoriatic arthritis in patients with moderate to severe psoriasis.
Methods: Data from patients with psoriasis and a reported history of comorbid psoriatic arthritis in 3 randomized, placebo-controlled psoriasis trials of adalimumab were analyzed.
Results: Adalimumab (n = 274) reduced the risk of psoriatic arthropathy adverse events by 75% versus placebo (1.1 vs. 4.8%; p = 0.025). Psoriasis/psoriatic arthritis-related pain was significantly reduced (-31.3 vs. -5.6 visual analog scale units; p < 0.0001). At week 16, adalimumab-treated patients were more likely to respond (56.9 vs. 4.5%; p < 0.001) and responded for a greater percentage of follow-up time (39.3 vs. 2.9%; p< 0.0001) than placebo-treated patients (regression model for PASI 75 and ACR 20 responses).
Conclusion: Adalimumab treatment of moderate to severe psoriasis reduced symptoms of comorbid psoriatic arthritis.
Copyright 2009 S. Karger AG, Basel.