Copper-catalyzed domino intra- and intermolecular C-S cross-coupling reactions: synthesis of 2-(arylthio)arylcyanamides

Tamminana Ramana; Prasenjit Saha; Manas Das; Tharmalingam Punniyamurthy

doi:10.1021/ol9024088

Copper-catalyzed domino intra- and intermolecular C-S cross-coupling reactions: synthesis of 2-(arylthio)arylcyanamides

Org Lett. 2010 Jan 1;12(1):84-7. doi: 10.1021/ol9024088.

Authors

Tamminana Ramana¹, Prasenjit Saha, Manas Das, Tharmalingam Punniyamurthy

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.

PMID: 19938846
DOI: 10.1021/ol9024088

Abstract

One-pot synthesis of 2-(arylthio)arylcyanamides is accomplished using cheap and air-stable CuSO(4) x 5 H(2)O as a catalyst by domino intra- and intermolecular C-S cross-coupling reactions of 2-(iodoaryl)thioureas with aryl iodides under ligand-free conditions.