The renaissance of alpha-methylene-gamma-butyrolactones: new synthetic approaches

Russell R A Kitson; Alessia Millemaggi; Richard J K Taylor

doi:10.1002/anie.200903108

The renaissance of alpha-methylene-gamma-butyrolactones: new synthetic approaches

Angew Chem Int Ed Engl. 2009;48(50):9426-51. doi: 10.1002/anie.200903108.

Authors

Russell R A Kitson¹, Alessia Millemaggi, Richard J K Taylor

Affiliation

¹ Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.

PMID: 19938025
DOI: 10.1002/anie.200903108

Abstract

The amount of research activity concerning alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones has increased dramatically in recent years. This Review summarizes the structural types, biological activities, and biosynthesis of these compounds, concentrating on publications from the past 10 years. Traditional approaches to alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones are then reviewed together with novel approaches, including those from our own research group, reported more recently.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / biosynthesis
4-Butyrolactone / chemical synthesis
4-Butyrolactone / therapeutic use
Drug Evaluation, Preclinical
Molecular Structure
Structure-Activity Relationship

Substances

alpha-methylene gamma-butyrolactone
4-Butyrolactone