Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes

Eur J Med Chem. 2010 Feb;45(2):564-71. doi: 10.1016/j.ejmech.2009.10.043. Epub 2009 Nov 4.

Abstract

Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Animals
  • Cattle
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • DNA / chemistry
  • DNA / metabolism*
  • Electrons
  • Free Radical Scavengers / chemical synthesis*
  • Free Radical Scavengers / metabolism*
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / toxicity
  • Humans
  • Hydroxyl Radical / chemistry
  • Nucleic Acid Denaturation
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / metabolism*
  • Organometallic Compounds / pharmacology
  • Organometallic Compounds / toxicity
  • Photochemical Processes*
  • Pyridines / chemistry*
  • Rats
  • Ruthenium / chemistry*
  • Spectrum Analysis
  • Transition Temperature
  • Viscosity

Substances

  • Free Radical Scavengers
  • Organometallic Compounds
  • Pyridines
  • Hydroxyl Radical
  • Ruthenium
  • DNA
  • pyridine