A large number of pigmentary disorders exist and although not all dermatologic entities are covered in this article, some of the pigmentary disorders that an internist or general practitioner is likely to encounter are reviewed. The clinician must be able to recognize pigmentary changes that suggest a serious underlying disease. In a situation where a malignancy or other serious illness may exist, an extensive evaluation to detect the disorder is required. This approach can allow for early treatment and referral to an appropriate specialist if necessary. The clinician must also recognize that pigmentary disorders that are essentially cosmetic still cause concern for the patient and can be emotionally distressing. These patients need emotional support and in some cases referral to a mental health specialist.