Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro

Int J Pharm. 2010 Feb 15;386(1-2):262-7. doi: 10.1016/j.ijpharm.2009.11.014. Epub 2009 Nov 20.

Abstract

Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by (1)H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG-PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Biphenyl Compounds / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Chemistry, Pharmaceutical
  • Chromatography, Gel
  • Dose-Response Relationship, Drug
  • Drug Carriers*
  • Female
  • Hemolysis / drug effects
  • Humans
  • Kinetics
  • Lignans / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Molecular Weight
  • Nanoparticles*
  • Nanotechnology
  • Ovarian Neoplasms / pathology
  • Particle Size
  • Polyesters / chemistry*
  • Polyesters / toxicity
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / toxicity
  • Solubility
  • Solvents / chemistry
  • Surface Properties
  • Technology, Pharmaceutical / methods

Substances

  • Antineoplastic Agents, Phytogenic
  • Biphenyl Compounds
  • Drug Carriers
  • Lignans
  • Polyesters
  • Solvents
  • methoxy poly(ethylene glycol)-poly(lactide)
  • honokiol
  • Polyethylene Glycols