Hamartoma are defined by the benign proliferation of cells normally occurring in the affected tissue or organ. The structure of the hyperplasic region can greatly differ from the normal histology of the affected tissue, due to the quantity, the layout, or the maturation state of tumoral cells. Hamartoma of the maxilla and mandible are a heterogeneous group of diseases. They nevertheless share two major therapeutic characteristics: surgical treatment of the mass effect and the deformations induced by tumoral growth and mandatory screening for associated extra-facial tumors.