alpha-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: a structure-activity relationships approach

Mini Rev Med Chem. 2009 Oct;9(12):1389-96. doi: 10.2174/138955709789957422.

Abstract

alpha-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Heterocyclic Compounds / chemistry
  • Metals / chemistry
  • Molecular Conformation
  • Ribonucleotide Reductases / antagonists & inhibitors
  • Ribonucleotide Reductases / metabolism
  • Structure-Activity Relationship
  • Thiosemicarbazones / chemistry*
  • Thiosemicarbazones / pharmacology

Substances

  • Antineoplastic Agents
  • Heterocyclic Compounds
  • Metals
  • Thiosemicarbazones
  • Ribonucleotide Reductases