Abstract
alpha-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Heterocyclic Compounds / chemistry
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Metals / chemistry
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Molecular Conformation
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Ribonucleotide Reductases / antagonists & inhibitors
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Ribonucleotide Reductases / metabolism
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Structure-Activity Relationship
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Thiosemicarbazones / chemistry*
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Thiosemicarbazones / pharmacology
Substances
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Antineoplastic Agents
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Heterocyclic Compounds
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Metals
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Thiosemicarbazones
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Ribonucleotide Reductases