Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives

F Fülöp; I Szatmári; E Vámos; D Zádori; J Toldi; L Vécsei

doi:10.2174/092986709789909602

Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives

Curr Med Chem. 2009;16(36):4828-42. doi: 10.2174/092986709789909602.

Authors

F Fülöp¹, I Szatmári, E Vámos, D Zádori, J Toldi, L Vécsei

Affiliation

¹ Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary. fulop@pharm.u-szeged.hu

PMID: 19929784
DOI: 10.2174/092986709789909602

Abstract

The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diabetes Mellitus / drug therapy
Humans
Ischemia / drug therapy
Kynurenic Acid / analogs & derivatives*
Kynurenic Acid / chemical synthesis*
Kynurenic Acid / pharmacology
Neurodegenerative Diseases / drug therapy
Renal Insufficiency / drug therapy
Schizophrenia / drug therapy

Substances

Kynurenic Acid