Use of allograft bone for posterior C1-2 fusion

J Neurosurg Spine. 2009 Oct;11(4):396-401. doi: 10.3171/2009.5.SPINE08662.

Abstract

Object: An iliac crest autograft is the gold standard for bone grafting in posterior atlantoaxial arthrodesis but can be associated with significant donor-site morbidity. Conversely, an allograft has historically performed suboptimally for atlantoaxial arthrodesis as an onlay graft. The authors have modified a bone grafting technique to allow placement of a bicortical iliac crest allograft in an interpositional manner, and they evaluated it as an alternative to an autograft in posterior atlantoaxial arthrodesis.

Methods: The records of 89 consecutive patients in whom C1-2 arthrodesis was performed between 2001 and 2005 were reviewed.

Results: Forty-seven patients underwent 48 atlantoaxial arthrodeses with an allograft (mean follow-up 16.1 months, range 0-49 months), and 42 patients underwent autograft bone grafting (mean follow-up 17.6 months, range 0-61.0 months). The operative time was 50 minutes shorter in the allograft (mean 184 minutes, range 106-328 minutes) than in the autograft procedure (mean 234 minutes, range 154-358 minutes), and the estimated blood loss was 50% lower in the allograft group than in the autograft group (mean 103 ml [range 30-200 ml] vs mean 206 ml [range 50-400 ml], respectively). Bone incorporation was initially slower in the allograft than in the autograft group but equalized by 12 months postprocedure. The respective fusion rates after 24 months were 96.7 and 88.9% for autografts and allografts. Complications at the donor site occurred in 16.7% of the autograft patients, including 1 pelvic fracture, 1 retained sponge, 1 infection, 2 hernias requiring repair, 2 hematomas, and persistent pain.

Conclusions: The authors describe a technique for interpositional bone grafting between C-1 and C-2 that allows for the use of an allograft with excellent fusion results. This technique reduced the operative time and blood loss and eliminated donor-site morbidity.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Atlanto-Axial Joint / surgery*
  • Axis, Cervical Vertebra / surgery
  • Blood Loss, Surgical
  • Bone Screws
  • Bone Transplantation / methods*
  • Cervical Atlas / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Ilium / transplantation*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Spinal Diseases / surgery*
  • Spinal Fusion / methods*
  • Transplantation, Homologous
  • Treatment Outcome
  • Young Adult