Abstract
The first Suzuki-Miyaura cross-couplings of carbamates, carbonates, and sulfamates is described. The method provides a powerful means of using simple derivatives of phenol as precursors to polysubstituted aromatic compounds, as exemplified by a concise synthesis of the anti-inflammatory drug flurbiprofen.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbamates / chemical synthesis*
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Carbamates / chemistry
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Carbonates / chemical synthesis*
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Carbonates / chemistry
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Flurbiprofen / chemical synthesis*
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Flurbiprofen / chemistry
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Molecular Structure
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Stereoisomerism
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Sulfonic Acids / chemical synthesis*
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Sulfonic Acids / chemistry
Substances
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Carbamates
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Carbonates
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Sulfonic Acids
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Flurbiprofen
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sulfamic acid