Photochemical stereospecific hydrogenation of a Ru complex with an NAD(+)/NADH-type ligand

Inorg Chem. 2009 Dec 21;48(24):11510-2. doi: 10.1021/ic901935u.

Abstract

A polypyridylruthenium complex with an NAD(+)/NADH model ligand, [Ru(bpy)(2)(pbn)](2+) [bpy = 2,2'-bipyridine; pbn = 2-(2-pyridyl)benzo[b]-1,5-naphthyridine] in a D(2)O/CH(3)CN/triethylamine solution, undergoes stereospecific hydrogenation to give Delta-(S)- and Lambda-(R)-[Ru(bpy)(2)(pbnDD)](2+) [pbnDD = 5,10-dideutero-2-(2-pyridyl)benzo[b]-1,5-naphthyridine] upon visible-light irradiation. This result clearly indicates the pathway via the pi-stacked dimer of the deuterated one-electron-reduced species. The reduction of [Ru(bpy)(2)(pbn)](2+) with Na(2)S(2)O(4) in D(2)O did not afford any stereospecific products. Furthermore, the more sterically crowded Ru complex, [Ru(dmb)(2)(pbn)](2+) (dmb = 6,6'-dimethyl-2,2'-bipyridine), did not produce the corresponding pbnDD species upon irradiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Crystallography, X-Ray
  • Hydrogen-Ion Concentration
  • Hydrogenation
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • NAD / chemistry*
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Photochemistry
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Ligands
  • Organometallic Compounds
  • NAD
  • Ruthenium