Increased yields and simplified purification with a second-generation cobalt catalyst for the oxidative formation of trans-THF rings

Cory Palmer; Nicholas A Morra; Andrew C Stevens; Barbora Bajtos; Ben P Machin; Brian L Pagenkopf

doi:10.1021/ol9023375

Increased yields and simplified purification with a second-generation cobalt catalyst for the oxidative formation of trans-THF rings

Org Lett. 2009 Dec 17;11(24):5614-7. doi: 10.1021/ol9023375.

Authors

Cory Palmer¹, Nicholas A Morra, Andrew C Stevens, Barbora Bajtos, Ben P Machin, Brian L Pagenkopf

Affiliation

¹ The University of Western Ontario, Department of Chemistry, London, Ontario, N6A 5B7.

PMID: 19925011
DOI: 10.1021/ol9023375

Abstract

The synthesis of a second-generation cobalt catalyst for the formation of trans-THF products via the Mukaiyama aerobic oxidative cyclization is reported. Two procedures have been developed with the new water-soluble catalyst that give superior yields and greatly simplify purification compared to the previous catalysts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cobalt / chemistry*
Combinatorial Chemistry Techniques*
Cyclization
Molecular Structure
Oxidation-Reduction
Solubility
Stereoisomerism
Water / chemistry

Substances

Water
Cobalt