Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV), the most recently identified member of the herpesvirus family, infects a variety of target cells in vitro and in vivo. This minireview surveys current information on the early events of KSHV infection, including virus-receptor interactions, involved envelope glycoproteins, mode of entry, intracellular trafficking, and initial viral and host gene expression programs. We describe data supporting the hypothesis that KSHV manipulates preexisting host cell signaling pathways to allow successful infection. The various signaling events triggered by infection, and their potential roles in the different stages of infection and disease pathogenesis, are summarized.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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B-Lymphocytes / metabolism
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B-Lymphocytes / virology
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Cells, Cultured
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DNA, Viral / genetics
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DNA, Viral / metabolism
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Endothelial Cells / metabolism
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Endothelial Cells / virology
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Focal Adhesion Protein-Tyrosine Kinases / genetics
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Focal Adhesion Protein-Tyrosine Kinases / metabolism
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Gene Expression Regulation, Viral
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Herpesviridae Infections / metabolism*
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Herpesvirus 8, Human / genetics
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Herpesvirus 8, Human / metabolism*
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Humans
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Keratinocytes / metabolism
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Keratinocytes / virology
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Microtubules / metabolism
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Monocytes / metabolism
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Monocytes / virology
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Phosphatidylinositol 3-Kinases / genetics
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Phosphatidylinositol 3-Kinases / metabolism
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Signal Transduction / physiology*
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / metabolism
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Virus Internalization
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Virus Latency
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rhoA GTP-Binding Protein / genetics
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rhoA GTP-Binding Protein / metabolism
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src-Family Kinases / genetics
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src-Family Kinases / metabolism
Substances
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DNA, Viral
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Viral Envelope Proteins
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Phosphatidylinositol 3-Kinases
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Focal Adhesion Protein-Tyrosine Kinases
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src-Family Kinases
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rhoA GTP-Binding Protein