Abstract
Electrochemically induced catalytic multicomponent transformation of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized indole-3,4'-pyrano[3,2-c]quinoline] scaffold in 75-91% substance yields and 500-600% current yield. The developed efficient electrocatalytic approach to medicinally relevant [indole-3,4'-pyrano[3,2-c]quinoline] scaffold is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reactions.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cyclization
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Efficiency
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Electrochemical Techniques / methods*
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry
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Hydroxyquinolines / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Isatin / chemistry*
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Macromolecular Substances / chemical synthesis*
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Macromolecular Substances / chemistry
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Models, Biological
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Nitriles / chemistry*
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Quinolones / chemistry*
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
Substances
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Heterocyclic Compounds
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Hydroxyquinolines
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Indoles
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Macromolecular Substances
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Nitriles
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Quinolones
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Spiro Compounds
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Isatin
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dicyanmethane
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4-hydroxyquinoline