Abstract
Among 40 Escherichia coli urine isolates from renal transplant recipients (Galveston, TX, 2003 to 2005), sequence type ST131 (O25:H4) was highly prevalent (representing 35% of isolates overall and 60% of fluoroquinolone-resistant isolates), virulent appearing, antimicrobial resistant (but extended-spectrum-cephalosporin susceptible), and associated with black race. Pulsotypes were diverse; some were linked to other locales. ST131 emerged significantly during the study period. These findings suggest that E. coli ST131 may constitute an important new multidrug-resistant threat to renal transplant recipients.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology*
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Bacteriophage phi X 174
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Black People
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial / genetics*
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Electrophoresis, Gel, Pulsed-Field
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Escherichia coli / genetics*
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Escherichia coli Infections / microbiology*
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Female
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Fluoroquinolones / pharmacology*
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Humans
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Kidney Transplantation*
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Logistic Models
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Phylogeny
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Reverse Transcriptase Polymerase Chain Reaction
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Serotyping
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Urinary Tract Infections / microbiology*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Fluoroquinolones
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beta-lactamase CTX-M-15
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beta-Lactamases