Sensory-motor axonal peripheral neuropathy in an advanced breast cancer patient treated with ixabepilone

Clin Transl Oncol. 2009 Nov;11(11):765-7. doi: 10.1007/s12094-009-0440-9.

Abstract

Ixabepilone is a novel microtubule-stabilising agent used as monotherapy or in combination with capecitabine to treat taxane- and anthracycline-refractory breast cancer. We report the case of a patient who experienced an unusual motor neuropathy after the first cycle. This is a very uncommon secondary effect, but it must be taken into account as a possible complication of treatment with ixabepilone.

Publication types

  • Case Reports

MeSH terms

  • Axons / metabolism*
  • Breast Neoplasms / complications*
  • Breast Neoplasms / drug therapy*
  • Epothilones / adverse effects*
  • Fatal Outcome
  • Female
  • Humans
  • Microtubules / metabolism
  • Middle Aged
  • Neurons, Afferent / drug effects*
  • Neurons, Afferent / metabolism*
  • Peripheral Nervous System Diseases / chemically induced*
  • Treatment Outcome
  • Tubulin Modulators / adverse effects

Substances

  • Epothilones
  • Tubulin Modulators
  • ixabepilone