Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues

Jin-Lan Yu; Qin-Pei Wu; Qing-Shan Zhang; Yan-Hong Liu; Yun-Zheng Li; Zi-Ming Zhou

doi:10.1016/j.bmcl.2009.10.127

Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues

Bioorg Med Chem Lett. 2010 Jan 1;20(1):240-3. doi: 10.1016/j.bmcl.2009.10.127. Epub 2009 Nov 4.

Authors

Jin-Lan Yu¹, Qin-Pei Wu, Qing-Shan Zhang, Yan-Hong Liu, Yun-Zheng Li, Zi-Ming Zhou

Affiliation

¹ School of Chemical Engineering & Environment, Beijing Institute of Technology, Beijing 100081, China.

PMID: 19917528
DOI: 10.1016/j.bmcl.2009.10.127

Abstract

A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
HeLa Cells
Hep G2 Cells
Humans
Magnetic Resonance Spectroscopy
Thionucleosides / chemical synthesis*
Thionucleosides / chemistry
Thionucleosides / pharmacology
Triazoles / chemistry*

Substances

Antineoplastic Agents
Thionucleosides
Triazoles