Abstract
Clinical and Laboratory Standards Institute changed penicillin susceptibility breakpoints for Streptococcus pneumoniae in 2008. After reevaluation with new breakpoints, resistance rates decreased from 6.1% to 0.5% for nonmeningitis and increased from 6.6% to 33.3% for meningitis isolates in our hospital. This breakpoint modification is expected to reduce the inconsistency between susceptibility results and therapeutic outcomes; however, both the clinical microbiology laboratories and the clinicians should be aware of the change to interpret the susceptibility results.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Academies and Institutes
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Hospitals, University
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Humans
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Laboratories, Hospital
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Microbial Sensitivity Tests / standards*
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Microbial Sensitivity Tests / statistics & numerical data
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Penicillin Resistance*
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Penicillins / pharmacology
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Penicillins / therapeutic use
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Pneumococcal Infections / drug therapy
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Pneumococcal Infections / microbiology*
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Streptococcus pneumoniae / drug effects*
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Treatment Outcome
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Turkey
Substances
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Anti-Bacterial Agents
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Penicillins