Concealed conduction effects in the atrium

IEEE Eng Med Biol Mag. 2009 Nov-Dec;28(6):24-9. doi: 10.1109/MEMB.2009.934628.

Abstract

A one-dimensional (1-D) model of the atrium together with the sinoatrial (SA) and atrioventricular (AV) nodes is presented in this article. The two nodes are each modeled by 15-element, diffusively coupled, modified van der Pol oscillator chains, while the atrium tissue is represented by a 90-element chain of diffusively coupled FitzHugh-Nagumo (FHN) equations. The modified van der Pol oscillators are able to reproduce physiologically important properties, such as the refraction period, phase-sensitivity properties, and modes of change of the action potential frequency. The activity of both branches of the autonomous nervous system may be introduced into the model in a simplified way. The model enables the study of the effect of the magnitude of the action potential conduction rate in the nodes on interspike intervals (ISIs; equivalent of RR intervals) and explains the occurrence of RR-interval alternans in certain patients. The effect of breathing modulation of heart rate and of a single deep breath can also be modeled. Finally, concealed conduction effects in the atrium are studied, yielding results comparable with recorded heart rate variability data.

MeSH terms

  • Atrial Function / physiology*
  • Atrioventricular Node / physiology*
  • Child
  • Female
  • Heart Rate / physiology*
  • Humans
  • Models, Cardiovascular*
  • Nonlinear Dynamics
  • Sinoatrial Node / physiology*