Hypomania with hypersexuality following bilateral anterior limb stimulation in obsessive-compulsive disorder

J Neurosurg. 2010 Jun;112(6):1299-300. doi: 10.3171/2009.10.JNS09918.

Abstract

This 28-year-old Chinese man was referred for deep brain stimulation (DBS) evaluation for an 8-year history of refractory obsessive-compulsive disorder. After the patient had signed an informed consent, the authors implanted DBS leads. Hypomania with hypersexuality was noted on stimulation at Contact 2 and became aggravated with a higher voltage (> or = 3 V) during chronic bilateral DBS. After the voltage was decreased to 1 V, the patient's hypomanic symptoms subsided and his libido returned to baseline.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Affect / physiology
  • Bipolar Disorder / physiopathology*
  • Brain Mapping
  • Deep Brain Stimulation / methods*
  • Depressive Disorder, Major / physiopathology
  • Depressive Disorder, Major / therapy
  • Dominance, Cerebral / physiology*
  • Electrodes, Implanted
  • Euphoria / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Obsessive-Compulsive Disorder / physiopathology
  • Obsessive-Compulsive Disorder / therapy*
  • Recurrence
  • Sexual Behavior / physiology*
  • Tomography, X-Ray Computed
  • Treatment Failure