Senescence and antibiotic resistance in an age-structured population model

J Math Biol. 2010 Oct;61(4):475-99. doi: 10.1007/s00285-009-0302-7. Epub 2009 Nov 12.

Abstract

Different theories have been proposed to understand the growing problem of antibiotic resistance of microbial populations. Here we investigate a model that is based on the hypothesis that senescence is a possible explanation for the existence of so-called persister cells which are resistant to antibiotic treatment. We study a chemostat model with a microbial population which is age-structured and show that if the growth rates of cells in different age classes are sufficiently close to a scalar multiple of a common growth rate, then the population will globally stabilize at a coexistence steady state. This steady state persists under an antibiotic treatment if the level of antibiotics is below a certain threshold; if the level exceeds this threshold, the washout state becomes a globally attracting equilibrium.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aging / physiology*
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / growth & development*
  • Bacterial Infections / drug therapy*
  • Bioreactors
  • Drug Resistance, Bacterial / drug effects*
  • Humans
  • Models, Biological*

Substances

  • Anti-Bacterial Agents