Abstract
Four new fluorescent derivatives of cholic acid have been synthesized; they incorporate a dansyl moiety at 3alpha-, 3beta-, 7alpha- or 7beta- positions. These cholic acid analogs are UV photoactive and also exhibit green fluorescence. In addition, they have been demonstrated to be suitable for studying the kinetics of bile acid transport by flow cytometry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cholic Acids / chemical synthesis*
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Cholic Acids / chemistry
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Cholic Acids / metabolism*
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Dansyl Compounds / chemical synthesis*
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Dansyl Compounds / chemistry
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Dansyl Compounds / metabolism*
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Flow Cytometry
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Fluorescence
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Kinetics
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Liver / cytology
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Liver / metabolism*
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Molecular Conformation
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Photochemistry
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Rats
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Stereoisomerism
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Ultraviolet Rays
Substances
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Cholic Acids
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Dansyl Compounds