Structurally diverse limonoids from the fruits of Swietenia mahagoni

J Nat Prod. 2009 Dec;72(12):2084-90. doi: 10.1021/np900522h.

Abstract

Eleven new mexicanolide-type limonoids, swietmanins A-I (1-4, 7-11), 2-hydroxy-3-O-isobutyrylproceranolide (5), 2-hydroxy-3-O-benzoylproceranolide (6), and a new andirobin-type limonoid, swietmanin J (12), together with 19 known compounds were isolated from the fruits of Swietenia mahagoni. Their structures were established on the basis of spectroscopic methods. These compounds were evaluated against a small panel of microorganisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Bacteria / drug effects
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Fruit / chemistry
  • Fungi / drug effects
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Limonins / pharmacology
  • Meliaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Drugs, Chinese Herbal
  • Limonins