Identification of an acetyl disulfide derivative in the synthesis of thiosialosides

Goreti Ribeiro Morais; Ines Felix Oliveira; Andrew J Humphrey; Robert A Falconer

doi:10.1016/j.carres.2009.10.017

Identification of an acetyl disulfide derivative in the synthesis of thiosialosides

Carbohydr Res. 2010 Jan 11;345(1):160-2. doi: 10.1016/j.carres.2009.10.017. Epub 2009 Oct 22.

Authors

Goreti Ribeiro Morais¹, Ines Felix Oliveira, Andrew J Humphrey, Robert A Falconer

Affiliation

¹ Institute of Cancer Therapeutics, School of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.

PMID: 19900671
DOI: 10.1016/j.carres.2009.10.017

Abstract

The first report of the formation of an acetyl disulfide sialoside during the synthesis of thioglycosides is described. This compound is a by-product in the synthesis of the 2-thioacetyl sialoside commonly used in thioglycoside preparation. Our investigations into the identification of this novel disulfide are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Disulfides / analysis*
Disulfides / chemistry*
Magnetic Resonance Spectroscopy
Thioglycosides / chemical synthesis*
Thioglycosides / chemistry*

Substances

Disulfides
Thioglycosides