Based on the field investigation data and related literatures, this paper analyzed the ecological issues in the breeding and utilization of highly cold-resistant and high-yielding rubber germplasm in Xishuangbanna, and the loss risk of this germplasm. The rubber farmers in Xishuangbanna had built a cycle pattern of establishing rubber nursery and managing rubber plantations to develop the local rubber industry, but the unlimited utilization of this germplasm made the rubber plantations expand to the highland with an elevation of 1300 m, resulting in the ecological issues such as the destruction of natural forests and species, decline of soil fertility, regional drought, rubber diseases and insect pests, and human-elephant conflicts. This germplsm and its intellectual property were under transnational loss without any control, making even more potential ecological and economic risks. Great attentions should be paid by the related organizations to take effective measures to conserve this germplsm resource to reduce its potential risks.