The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

Arch Pharm Res. 2009 Oct;32(10):1433-9. doi: 10.1007/s12272-009-2013-4. Epub 2009 Nov 8.

Abstract

The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzoates / isolation & purification
  • Benzoates / pharmacology*
  • Blotting, Western
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Collagen Type I / metabolism
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Fibroblasts / drug effects*
  • Fibroblasts / enzymology
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Humans
  • Matrix Metalloproteinase 1 / biosynthesis
  • Matrix Metalloproteinase Inhibitors*
  • Molecular Structure
  • Skin / cytology
  • Skin / drug effects*
  • Skin / enzymology
  • Skin Aging / drug effects

Substances

  • Benzoates
  • Collagen Type I
  • Enzyme Inhibitors
  • Glucosides
  • Matrix Metalloproteinase Inhibitors
  • curculigoside
  • MMP1 protein, human
  • Matrix Metalloproteinase 1