Abstract
The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzoates / isolation & purification
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Benzoates / pharmacology*
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Blotting, Western
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Cell Proliferation / drug effects
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Cells, Cultured
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Collagen Type I / metabolism
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Fibroblasts / drug effects*
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Fibroblasts / enzymology
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Humans
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Matrix Metalloproteinase 1 / biosynthesis
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Matrix Metalloproteinase Inhibitors*
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Molecular Structure
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Skin / cytology
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Skin / drug effects*
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Skin / enzymology
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Skin Aging / drug effects
Substances
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Benzoates
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Collagen Type I
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Enzyme Inhibitors
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Glucosides
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Matrix Metalloproteinase Inhibitors
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curculigoside
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MMP1 protein, human
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Matrix Metalloproteinase 1