Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives; Benjamin Le Calvé; Tamara Delaine; Laurent Legentil; Robert Kiss; Evelyne Delfourne

doi:10.1016/j.ejmech.2009.10.019

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Eur J Med Chem. 2010 Jan;45(1):343-51. doi: 10.1016/j.ejmech.2009.10.019. Epub 2009 Oct 14.

Authors

Arnaud Rives¹, Benjamin Le Calvé, Tamara Delaine, Laurent Legentil, Robert Kiss, Evelyne Delfourne

Affiliation

¹ Université Paul Sabatier, UMR CNRS 5068, Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, 118 route de Narbonne, 31062 Toulouse Cédex 9, France.

PMID: 19897281
DOI: 10.1016/j.ejmech.2009.10.019

Abstract

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Inhibitory Concentration 50
Oceans and Seas
Quinolines / chemical synthesis*
Quinolines / chemistry
Quinolines / pharmacology*

Substances

Antineoplastic Agents
Quinolines