Molecular identification of phaeohyphomycosis due to Alternaria infectoria in a patient with acute myeloid leukemia--a case report

Diagn Microbiol Infect Dis. 2010 Mar;66(3):318-21. doi: 10.1016/j.diagmicrobio.2009.09.019. Epub 2009 Nov 5.

Abstract

We report the case of a 15-year old with acute myeloid leukemia who developed breakthrough invasive fungal rhinitis. The fungus was identified as Alternaria infectoria by polymerase chain reaction (PCR) and successfully treated by surgical excision and combination antifungal therapy, emphasizing the utility of fungal PCR in timely diagnosis of invasive fungal infections.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Alternaria / genetics*
  • Alternaria / isolation & purification
  • Antifungal Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cytarabine / therapeutic use
  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Immunocompromised Host
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / microbiology*
  • Mycoses / complications
  • Mycoses / diagnosis
  • Mycoses / drug therapy
  • Mycoses / microbiology*
  • Nasal Cavity / microbiology
  • Polymerase Chain Reaction
  • Rhinitis / complications
  • Rhinitis / diagnosis
  • Rhinitis / drug therapy
  • Rhinitis / microbiology*
  • Vidarabine / analogs & derivatives
  • Vidarabine / therapeutic use

Substances

  • Antifungal Agents
  • Cytarabine
  • Granulocyte Colony-Stimulating Factor
  • Vidarabine

Supplementary concepts

  • FLAG protocol