Abstract
We report a case of morphologically microgranular acute promyelocytic leukemia with PML/RARA fusion transcripts demonstrated by reverse transcriptase-PCR and cDNA sequencing, and no PML/RARA fusion detected by karyotype and FISH analyses. Karyotype was 47,XX,+8[19]/46,XX[1]. Although the newer FISH probes provide more accurate detections of t(15;17), it would be necessary to perform other molecular tests to further identify the masked PML/RARA fusions.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Chromosomes, Human, Pair 15 / genetics*
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Chromosomes, Human, Pair 17 / genetics*
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Chromosomes, Human, Pair 8
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Female
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Humans
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In Situ Hybridization, Fluorescence / methods
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Karyotyping / methods
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Leukemia, Promyelocytic, Acute / diagnosis
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Leukemia, Promyelocytic, Acute / genetics*
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Leukemia, Promyelocytic, Acute / pathology
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Middle Aged
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Oncogene Proteins, Fusion / genetics*
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Reverse Transcriptase Polymerase Chain Reaction / methods*
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Sequence Analysis, DNA / methods*
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Translocation, Genetic*
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Trisomy
Substances
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Oncogene Proteins, Fusion
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promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein