Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus

J Trop Pediatr. 2010 Aug;56(4):242-6. doi: 10.1093/tropej/fmp101. Epub 2009 Nov 3.

Abstract

Objective: To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).

Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and 108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele's frequencies of SNPs were analyzed with case-control study, linkage of two loci and haplotypes composed by the two loci were also studied.

Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01).

Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Child, Preschool
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Haplotypes*
  • Humans
  • Infant
  • Interleukin-8 / genetics*
  • Linkage Disequilibrium
  • Logistic Models
  • Male
  • Polymorphism, Single Nucleotide
  • Respiratory Syncytial Virus Infections / genetics*
  • Respiratory Syncytial Viruses / genetics
  • Respiratory Syncytial Viruses / isolation & purification*
  • Sequence Analysis, DNA

Substances

  • CXCL8 protein, human
  • Interleukin-8