Total synthesis of the 2,6-sialylated immunoglobulin G glycopeptide fragment in homogeneous form

J Am Chem Soc. 2009 Nov 25;131(46):16669-71. doi: 10.1021/ja907136d.

Abstract

The 2,6-sialylated tridecasaccharide 1 associated with the Fc fragment of intravenous immunoglobulin has been synthesized.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Glycopeptides / chemical synthesis*
  • Glycopeptides / chemistry
  • Glycopeptides / immunology*
  • Immunoglobulin Fc Fragments / chemistry*
  • Immunoglobulins, Intravenous / chemistry*
  • Polysaccharides / chemical synthesis*
  • Polysaccharides / chemistry
  • Polysaccharides / immunology*

Substances

  • Glycopeptides
  • Immunoglobulin Fc Fragments
  • Immunoglobulins, Intravenous
  • Polysaccharides