Abstract
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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DNA / metabolism*
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Drug Design
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Histone Deacetylase 1 / antagonists & inhibitors
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Histone Deacetylase Inhibitors / chemistry*
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Histone Deacetylase Inhibitors / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Platinum Compounds / chemistry
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Platinum Compounds / pharmacology*
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Platinum Compounds / therapeutic use
Substances
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Antineoplastic Agents
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Histone Deacetylase Inhibitors
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Platinum Compounds
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DNA
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HDAC1 protein, human
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Histone Deacetylase 1