Abstract
1-Hydroxy-2-dodecyl-4(1H)quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis.
MeSH terms
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Animals
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Antiparasitic Agents / pharmacology*
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Antiparasitic Agents / therapeutic use
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Cells, Cultured
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DNA, Protozoan / analysis
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Female
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Fibroblasts / drug effects
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Fibroblasts / parasitology
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Flow Cytometry
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Humans
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Liver / chemistry
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Liver / parasitology
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Lung / chemistry
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Lung / parasitology
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Mice
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Peritoneal Cavity / cytology
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Peritoneal Cavity / parasitology
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Quinolones / pharmacology*
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Quinolones / therapeutic use
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Reverse Transcriptase Polymerase Chain Reaction
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Toxoplasma / drug effects*
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Toxoplasmosis, Animal / drug therapy*
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Toxoplasmosis, Animal / parasitology
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Toxoplasmosis, Cerebral / drug therapy
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Toxoplasmosis, Cerebral / parasitology
Substances
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Antiparasitic Agents
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DNA, Protozoan
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Quinolones