Abstract
Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Chronic Disease
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Cimetidine / adverse effects*
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Cimetidine / pharmacology
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Clozapine / adverse effects*
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Clozapine / blood
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Clozapine / pharmacokinetics
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Drug Interactions
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Drug Therapy, Combination
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Humans
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Male
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Ranitidine / pharmacokinetics
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Ranitidine / therapeutic use
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Schizophrenia, Paranoid / drug therapy*
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Schizophrenia, Paranoid / psychology
Substances
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Cimetidine
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Ranitidine
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Clozapine