A case report of cimetidine-induced clozapine toxicity

J Clin Psychiatry. 1991 Jan;52(1):21-2.

Abstract

Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Chronic Disease
  • Cimetidine / adverse effects*
  • Cimetidine / pharmacology
  • Clozapine / adverse effects*
  • Clozapine / blood
  • Clozapine / pharmacokinetics
  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Male
  • Ranitidine / pharmacokinetics
  • Ranitidine / therapeutic use
  • Schizophrenia, Paranoid / drug therapy*
  • Schizophrenia, Paranoid / psychology

Substances

  • Cimetidine
  • Ranitidine
  • Clozapine