Purpose: To report 2 cases of delayed spontaneous Descemet membrane (DM) reattachment following big-bubble deep anterior lamellar keratoplasty (DALK).
Methods: A 21-year-old man with keratoconus and a 36-year-old woman with corneal macular dystrophy underwent big-bubble DALK. No injury to DM was noted intraoperatively or postoperatively. Postoperatively, the patients developed central DM detachment with double anterior chamber formation. A nonsurgical conservative approach (waiting technique) was adopted.
Results: Three weeks postoperatively, the double anterior chamber resolved spontaneously with complete DM reattachment and a clear donor cornea.
Conclusions: DM detachment and double anterior chamber following big-bubble DALK may resolve spontaneously.