An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders: II. Tolerability and pharmacokinetics

J Child Adolesc Psychopharmacol. 2009 Oct;19(5):493-9. doi: 10.1089/cap.2008.0126.

Abstract

Objective: The aim of this study was to evaluate the tolerability of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD).

Methods: This was a two-phase, 7-week, open study in children aged 6-17 years. Phase 1 initiated ATMX for a minimum of 4 weeks. Phase 2 entered partial responders to ATMX and added OROS MPH to their regimen. Safety was assessed using blood pressure and heart rate measurements, electrocardiogram readings, AEs, laboratories, and ATMX levels.

Results: Fifty subjects who were partial responders to ATMX received the combination therapy, with 41 subjects completing the entire protocol. As reported elsewhere (Wilens et al., 2009 ), OROS MPH added to partial responders of ATMX was accompanied by a 40% reduction in the ADHD rating scale score and improvements in executive functioning. However, the combination of ATMX plus OROS MPH was associated with greater rates of insomnia, irritability, and loss of appetite compared to ATMX alone. A small significant increase in diastolic blood pressure was observed during adjunctive OROS MPH, with no clinically meaningful changes in electrocardiogram (ECG) parameters during the study. ATMX levels and liver function tests did not significantly change during the combination treatment.

Conclusion: Adjunct OROS MPH in ATMX partial responders yielded an additive adverse effect burden in this short-term study. Further controlled research with larger samples of children is warranted.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenergic Uptake Inhibitors / adverse effects*
  • Adrenergic Uptake Inhibitors / pharmacokinetics
  • Adrenergic Uptake Inhibitors / therapeutic use
  • Atomoxetine Hydrochloride
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Blood Pressure / drug effects
  • Central Nervous System Stimulants / adverse effects*
  • Central Nervous System Stimulants / pharmacokinetics
  • Central Nervous System Stimulants / therapeutic use
  • Child
  • Delayed-Action Preparations
  • Drug Therapy, Combination
  • Electrocardiography
  • Female
  • Heart Rate / drug effects
  • Humans
  • Liver Function Tests
  • Male
  • Methylphenidate / adverse effects*
  • Methylphenidate / pharmacokinetics
  • Methylphenidate / therapeutic use
  • Propylamines / adverse effects*
  • Propylamines / pharmacokinetics
  • Propylamines / therapeutic use

Substances

  • Adrenergic Uptake Inhibitors
  • Central Nervous System Stimulants
  • Delayed-Action Preparations
  • Propylamines
  • Methylphenidate
  • Atomoxetine Hydrochloride