How to control miRNA maturation?

RNA Biol. 2009 Nov-Dec;6(5):536-40. doi: 10.4161/rna.6.5.10080.

Abstract

In this point of view we discuss the role of co-activators and co-repressors of miRNA precursors maturation, the possibility that their functions are post translationally regulated by different signaling pathways, and their potential role in the miRNA-dependent control of cell proliferation and differentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation
  • Cell Proliferation
  • Co-Repressor Proteins / physiology
  • Humans
  • MicroRNAs / metabolism*
  • RNA Precursors / metabolism*
  • RNA Processing, Post-Transcriptional*
  • Ribonuclease III / metabolism
  • Signal Transduction
  • Transcription Factors / physiology

Substances

  • Co-Repressor Proteins
  • MicroRNAs
  • RNA Precursors
  • Transcription Factors
  • DROSHA protein, human
  • Ribonuclease III