Abstract
The synthesis of new N-homopiperazinyl-based ligands is reported. Various structural modifications along with the corresponding biological activities on 5-HT(1A)/5-HT(7) receptors give further insights into this class of serotoninergic ligands. Among the tested central heterocyles, the 7-azaindole gave the best results on the above-mentioned receptors.
MeSH terms
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Drug Design
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Humans
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Indoles
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Ligands
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Piperazine
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Piperazines / chemical synthesis
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Piperazines / chemistry*
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Piperazines / pharmacology
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Protein Binding
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Radioligand Assay
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Receptor, Serotonin, 5-HT1A
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Receptors, Serotonin
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Serotonin Receptor Agonists / chemical synthesis
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Serotonin Receptor Agonists / chemistry*
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Structure-Activity Relationship
Substances
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7-azaindole dimer
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Indoles
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Ligands
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Piperazines
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Receptors, Serotonin
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Serotonin Receptor Agonists
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serotonin 7 receptor
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Receptor, Serotonin, 5-HT1A
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Piperazine