Abstract
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / metabolism
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Capsaicin / analogs & derivatives
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Capsaicin / chemical synthesis
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Capsaicin / chemistry
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Capsaicin / pharmacology
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Halogenation / drug effects
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Intracellular Space / drug effects
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Intracellular Space / metabolism
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Intracellular Space / radiation effects
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Lasers
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Ligands
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Light*
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Membrane Potentials / drug effects
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Photolysis / drug effects
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Photolysis / radiation effects*
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Rats
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Rats, Wistar
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TRPV Cation Channels / agonists*
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TRPV Cation Channels / antagonists & inhibitors*
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Trigeminal Nerve / cytology
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Trigeminal Nerve / drug effects
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Trigeminal Nerve / radiation effects
Substances
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Ligands
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TRPV Cation Channels
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TRPV1 receptor
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Capsaicin
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nonivamide
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Calcium