The role of angiogenesis in the pathogenesis of psoriasis

Autoimmunity. 2009 Nov;42(7):574-9. doi: 10.1080/08916930903002461.

Abstract

Psoriasis is a multifactorial skin disorder with known systemic consequences. While most recent studies point to a predominantly Th17-driven process, psoriasis also lies at the crossroads linking the pathways of angiogenesis and inflammation. Mediators such as VEGF and angiopoietin-2 play significant roles in the pathophysiology and may even account for the maintenance of the chronic inflammatory state. Targets in this shared pathway may offer alternative avenues for therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Antibodies, Monoclonal / therapeutic use
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Humans
  • Immunologic Factors / therapeutic use
  • Neovascularization, Pathologic / immunology*
  • Neovascularization, Pathologic / metabolism
  • Psoriasis / drug therapy
  • Psoriasis / immunology*
  • Psoriasis / metabolism
  • Signal Transduction / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism
  • Vascular Endothelial Growth Factor A / immunology*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Cytokines
  • Immunologic Factors
  • Vascular Endothelial Growth Factor A