Mechanisms of HTLV-1 persistence and transformation

Br J Cancer. 2009 Nov 3;101(9):1497-501. doi: 10.1038/sj.bjc.6605345. Epub 2009 Sep 29.

Abstract

Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Basic-Leucine Zipper Transcription Factors / physiology
  • Cell Transformation, Viral
  • DNA Damage
  • Gene Products, rex / physiology
  • Gene Products, tax / physiology
  • Genomic Instability
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / physiology*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / pathology
  • Leukemia-Lymphoma, Adult T-Cell / virology
  • Retroviridae Proteins
  • T-Lymphocytes / pathology*
  • Viral Proteins / physiology
  • Virus Replication

Substances

  • Basic-Leucine Zipper Transcription Factors
  • Gene Products, rex
  • Gene Products, tax
  • HBZ protein, human T-cell leukemia virus type I
  • Retroviridae Proteins
  • Viral Proteins
  • rex Protein, Human T-lymphotropic virus 1
  • tax protein, Human T-lymphotrophic virus 1