Abstract
The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.76 x 10(-8) for cisplatin) and so distinctly better than free ligand and other complexes.
Copyright 2009 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Biomimetic Materials / chemistry
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Carbon / chemistry
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Carcinoma, Ehrlich Tumor / drug therapy*
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Carcinoma, Ehrlich Tumor / pathology
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Cell Death / drug effects
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Cell Line, Tumor
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Electrochemistry
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Female
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Glycosylation
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Magnetics
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Mice
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Organometallic Compounds / therapeutic use
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Saccharin / chemistry
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Semicarbazides / chemistry*
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Spectrum Analysis
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Temperature
Substances
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Antineoplastic Agents
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Organometallic Compounds
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Semicarbazides
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thiosemicarbazide
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Carbon
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Saccharin