Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice

Eur J Med Chem. 2010 Jan;45(1):106-13. doi: 10.1016/j.ejmech.2009.09.031. Epub 2009 Sep 28.

Abstract

The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.76 x 10(-8) for cisplatin) and so distinctly better than free ligand and other complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biomimetic Materials / chemistry
  • Carbon / chemistry
  • Carcinoma, Ehrlich Tumor / drug therapy*
  • Carcinoma, Ehrlich Tumor / pathology
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Electrochemistry
  • Female
  • Glycosylation
  • Magnetics
  • Mice
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Organometallic Compounds / therapeutic use
  • Saccharin / chemistry
  • Semicarbazides / chemistry*
  • Spectrum Analysis
  • Temperature

Substances

  • Antineoplastic Agents
  • Organometallic Compounds
  • Semicarbazides
  • thiosemicarbazide
  • Carbon
  • Saccharin