Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent

Zhi Zhang; Rui He; Kun Yan; Qian-ni Guo; Yun-guo Lu; Xu-xia Wang; Hao Lei; Zao-ying Li

doi:10.1016/j.bmcl.2009.10.003

Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6675-8. doi: 10.1016/j.bmcl.2009.10.003. Epub 2009 Oct 4.

Authors

Zhi Zhang¹, Rui He, Kun Yan, Qian-ni Guo, Yun-guo Lu, Xu-xia Wang, Hao Lei, Zao-ying Li

Affiliation

¹ College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.

PMID: 19850475
DOI: 10.1016/j.bmcl.2009.10.003

Abstract

5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Proliferation / drug effects
Contrast Media / chemical synthesis*
Contrast Media / pharmacology
Dextrans / chemical synthesis
Dextrans / chemistry
Dextrans / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Magnetic Resonance Imaging / methods
Metalloporphyrins / chemical synthesis
Metalloporphyrins / chemistry
Metalloporphyrins / pharmacology*
Molecular Structure
Time Factors

Substances

Contrast Media
Dextrans
Metalloporphyrins